2018 Planning Committee

 

 

Christine Brezden-Masley, MD, PhD, FRCPC

Associate Professor of Medicine, University of Toronto; Head, Division of Hematology/Oncology, St. Michael's Hospital, Toronto, ON, Canada. President, Canadian Cardiac Oncology Network

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Dr. Christine Brezden-Masley is a practicing Medical Oncologist and the Division Head of Hematology / Oncology at St. Michael’s Hospital in Toronto. She is the Co-Director of the Hematology/Oncology Clinical Research Group there. She obtained her PhD in Medical Biophysics at Princess Margaret Hospital in Toronto and her Medical Degree from the University of Toronto. She is currently an Associate Professor at the University of Toronto and an Associate Scientist at the Li Ka Shing Knowledge Institute. 

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She is the founder of the COMET (Community Oncologists of Metropolitan Toronto) Clinical Trials Consortium, a web-based virtual network promoting cancer clinical trials throughout the Toronto Region. She treats both Breast and GI (colorectal and gastric cancers) malignancies and these are the major areas of her clinical research. Her main area of clinical research is cardiotoxicity from cancer therapy and has been the Co-Chair of the Annual Canadian Cardio-Oncology Network meeting, a collaborative national meeting improving cardiac heath in cancer patients. She is currently the President of the Canadian Cardio-Oncology Network. She is active in research, education and has been instrumental in the clinical development of the cancer program at St. Michael’s Hospital.

Susan Dent, MD, FRCPC

Professor, Department of Medicine, University of Ottawa; Medical Oncologist, The Ottawa Hospital Cancer Centre, Ottawa, ON, Canada. Founder & Past-President, Canadian Cardiac Oncology Network

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Dr. Dent is a Medical Oncologist at The Ottawa Hospital Cancer Centre and Professor in the Department of Medicine at the University of Ottawa.  She obtained her MD at McMaster University and completed her postgraduate training in Internal Medicine at the University of Ottawa. She continued her training in Medical Oncology in Ottawa, followed by a fellowship year in Clinical Research with the National Cancer Institute of Canada Clinical Trials Group. 

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She is the research lead for the breast disease site group at the Ottawa Hospital Cancer Centre, and a member of the IND working group for the Breast Cancer Disease Site Committee of the National Cancer Institute for Canada Clinical Trials Group. Her areas of research interest include breast cancer, and treatment related toxicities with a particular interest in cardiotoxicity. She is the founder of the Ottawa Cardiac Oncology Program as well as the Canadian Cardiac Oncology Network, organizations dedicated to improving our understanding of how cancer treatments impact cardiovascular health with the ultimate goal of preventing cardiotoxicity. She established the first multidisciplinary cardio-oncology clinic in Canada in 2008 and since that time has travelled around the world (India, China, Chile) assisting other centers in establishing similar clinics. She is active in cardio-oncology education, having co-authored 3 book chapters  in cardio-oncology (2016/2017) and 3 position statements/guidelines (Canadian Cardiology Society, American Society of Clinical Oncology, European Society of Cardiology).

Michael G. Fradley, MD

GCOS 2018 Co-Chair; Assistant Professor of Medicine, University of South Florida; Cardiologist and Director, Cardio-Oncology Program, Moffitt Cancer Center and Research Institute, Tampa, FL, USA

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Dr. Fradley is an Assistant Professor of Medicine at the University of South Florida with a joint appointment as an Assistant Member at the H. Lee Moffitt Cancer Center and Research Institute. He is the director of the combined Moffitt Cancer Center-University of South Florida Cardio-Oncology program. He earned his B.S at Yale University and his MD degree at the Johns Hopkins University School of Medicine. 

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He remained at Johns Hopkins for internal medicine residency and then went on to complete fellowships in both cardiology and clinical cardiac electrophysiology at Massachusetts General Hospital. His research focuses on all aspects of cardio-oncology, however as a trained electrophysioloigst, Dr. Fradley has particular interest in the diagnosis and management of arrhythmic complications associated with traditional and novel cancer therapies. He has co-authored numerous articles in the field of cardio-oncology. He is also actively involved in undergraduate and graduate medical education mentoring medical students, residents and fellows. He developed and serves as the program director for cardio-oncology fellowship at the University of South Florida and Moffitt Cancer Center. He is the co-director of the biomedical research tract in the Scholarly Concentrations Program at the University of South Florida, Morsani College of Medicine. He is also the medical director for the Harvey Simulation Elective and teaches the cardiovascular pathophysiology course for the second year medical students.  

Eric Harrison, MD

Medical Director, Tampa Memorial Hospital;, Cardiologist, Harrison Cardiovascular Centre, Tampa, FL, USA

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Dr. Harrison is currently the National Director of Advanced Cardiac Imaging of Iasi Healthcare Inc.  which owns and operates 15 acute care hospitals in  Florida, Texas, Louisiana,  Utah, Arizona, and Nevada. Dr. Harrison was one of first to use the therapeutic hypothermia for Cardiac Arrest patients. He began to use this treatment clinically shortly after the landmark articles were published in February 2002.

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He is currently integrating hypothermic medicine into the IASIS healthcare system. He has served as a consultant for many national companies associated with cardiac imaging. Dr. Harrison started and directs the Joint Memorial Hospital / University of South Florida Medical School Advanced Cardiac Imaging Program for practicing  physicians , cardiac fellows, and medical student training. He is a preceptor for the University of South Florida Medical School and Saba University Medical School of the  Netherland Antilles. Dr. Harrison received his medical degree from the University of Kentucky and completed internship, Internal Medicine residency and Cardiology Fellowship at the University of South Florida  where he was a Special Fellow of the Florida Heart Association. He was acting Director of the Cath Lab at the VA Hospital  for 3 month prior to finishing his training. He is a founding physician of the University of South Florida Medical School. Dr. Harrison's experience in cardiology covers a broad spectrum. He was co-director of the Cardiology Center at Tampa General Hospital for thirteen years and directed noninvasive cardiology for seven years where he started echocardiography and nuclear cardiology. At Tampa General he performed over 14,000 heart catheterizations, numerous coronary angioplasties, cardiac electrophysiologic studies and myocardial biopsies and was a transplant cardiologist on the transplant team for three years. His first transplant patient has survived  over 20 years. He and his colleagues started the first outpatient cardiovascular health center in Tampa at Memorial Hospital where he is currently the Medical Director and where he has directed the cardiac rehabilitation program. His non-invasive cardiology interests are 3D echo, multislice CAT scan imaging of the coronaries, Cardiac PET/CT, Cardiac MRI, and hybrid imaging.

Roohi Ismail-Khan, MD, MSc

GCOS 2018 Co-Chair; Medical Oncologist and Co-Director, Cardio-Oncology Program, Moffitt Cancer Center and Research Institute, Tampa, FL, USA

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Dr. Roohi Ismail-Khan is a medical oncologist in the Department of Breast Oncology at Moffitt Cancer Center. Dr. Ismail-Khan’s research interests include reducing or eliminating long-term effects of chemotherapy to improve quality of life. Dr. Ismail-Khan’s research interests include reducing or eliminating long-term effects of chemotherapy to improve quality of life. 

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She is also focused on triple negative breast cancer; an aggressive disease that may respond well to chemotherapy, but often recurs and spreads. She serves as principal investigator on multiple investigator and pharmaceutical sponsored clinical trials. She is the co-director of the new Cardio-Oncology program working closely with Dr. Fradley, director of the program. Dr. Ismail-Kahn is also an active teacher/mentor for USF medical students, internal medicine USF residents, and medical oncology fellows.

Daniel J. Lenihan, MD, FACC

Professor of Medicine; Director, Cardio-Oncology Center of Excellence, Washington University Medical Center, St Louis, MO, USA. President, International Cardio-Oncology Society

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Dr. Lenihan, has been active in cardio-oncology and heart failure, for nearly 20 years. The main focus of these efforts have included hemodynamic assessments, angiogenic growth factor response, novel cardiac biomarkers as well as optimal methods to prevent or detect heart failure at the earliest stage possible in patients undergoing treatment for cancer.

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His current projects include early phase clinical trials in cardio-oncology, heart failure and amyloidosis.  He is the PI of the PROTECT study looking at cardiac safety in patients undergoing proteasome inhibitor treatment for multiple myeloma and recently completed the PREDICT study, a large multicenter prospective study examining the role of cardiac biomarkers for the detection of cardiotoxicity and has been intimately involved in the latest treatment trials for cardiac amyloidosis.  He recently moved to Washington University in St Louis to enhance and expand their Cardio-Oncology Center of Excellence.  Dr Lenihan continues to enhance and foster collaboration among a host of colleagues both regionally, nationally, and throughout the world. He is the current president of the International Cardio-Oncology Society (ICOS), a professional association whose primary goal is to eliminate cardiac disease as a barrier to effective cancer therapy.

Alexander Lyon, MA, BM, BCh, PhD, FRCP, FHFA

Senior Lecturer in Cardiology, Imperial College London; Consultant Cardiologist & Clinical Lead for Cardio-Oncology Service, Royal Brompton Hospital, London, United Kingdom. President, British Cardio-Oncology Society.

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Dr. Alexander Lyon is a Senior Lecturer in Cardiology at Imperial College London and a Consultant Cardiologist at the Royal Brompton Hospital. His clinical interests are in the field of heart failure, cardio-oncology including chemotherapy cardiomyopathy and the cardiovascular complications of modern cancer therapies, Takotsubo syndrome, and the development of novel therapeutics including gene therapy for chronic heart failure.

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Dr. Lyon is the clinical lead for the Cardio-Oncology service at the Royal Brompton Hospital since 2011, specialising in surveillance and cardioprotection from modern cancer drugs, risk stratification and treatment of all cardiac complications of cancer treatment. He is the current president of the British Cardio-Oncology Society (formerly the UK Cardio-Oncology Consortium) and the cardiology advisor to the charity Macmillan Cancer. Dr. Lyon was recently appointed chair of the European Society of Cardiology Heart Failure Association Cardio-Oncology Study Group and he is a co-author of their ESC Position Statement on Cardio-Oncology. He is a member of the International Cardio-Oncology Society and is co-chair of the 2017 ICOS-BCOS hosted Global Cardio-Oncology Summit in London.

Aarti A. Patel, MD

Director, Advanced Cardiovascular Imaging Fellowship, Assistant Professor of Medicine, Department of Cardiovascular Sciences, University of South Florida, Morsani College of Medicine, Tampa, FL, USA

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Dr. Patel is an Assistant Professor of Medicine at the University of South Florida (USF) with clinical appointments at Moffitt Cancer Center, James A. Haley Veterans’ Affairs Hospital and Tampa General Hospital. As a practicing cardiologist, her clinical expertise is in Advanced Cardiac Imaging, including echocardiography, cardiac magnetic resonance imaging and cardiac computed tomography. 

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She earned her Bachelor of Science degree at University of Miami (UM) and her Medical Doctorate at Florida State University College of Medicine. After completing residency at UM she completed both general and imaging fellowships at USF, later joining as faculty. She has special interest in multimodality imaging in diagnosis of cardiovascular disease and medical education. Her research interests include cardiomyopathy in Friedreich’s Ataxia and valvular disease. She has authored papers in cardio-oncology pertaining to multimodality imaging and medical education. She currently serves as the Director of the Advanced Cardiac Imaging Fellowship Program at USF and is a member of the American College of Cardiology Academic Council.

Javier Pinilla-Ibarz, MD, PhD

Senior Member, Head of the Lymphoma Section, Director of Immunotherapy, Department of Malignant Hematology, Moffitt Cancer Center; Professor of Oncologic Sciences, College of Medicine, University of South Florida, Tampa, FL, USA

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Javier Pinilla-Ibarz, MD, PhD, is a Senior Member, Head of the Lymphoma Section and Director of Immunotherapy in the Department of Malignant Hematology at the H. Lee Moffitt Cancer Center in Tampa, Florida. Dr. Pinilla-Ibarz is also a Professor in the Department of Oncologic Sciences, College of Medicine, University of South Florida, Tampa, Florida. 

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Dr. Pinilla-Ibarz has been leading the chronic leukemia program at Moffitt since 2006; and its principal interests in the clinic are patients with myeloid and lymphoid chronic leukemia. In this regard, Dr. Pinilla-Ibarz has participated in multiple clinical trials involving tyrosine kinase inhibitors, some of them now approved. As Director of Immunotherapy for Malignant Hematology, he has been involved in developing new immunotherapeutic approaches in malignant hematology. He has participated in several clinical trials of peptide and cellular vaccines in different hematological disorders. His laboratory is interested in epigenetic immunoregulation in lymphoid and myeloid leukemias. Other research focuses are on the role of the bone marrow microenvironment in mediating resistance to TKIs and the interaction of TKIs with the immune system. Dr. Pinilla-Ibarz frequently presents his findings at annual meetings of the American Hematology Association and the American Society of Clinical Oncology and other national/international meetings. His work has been published in journals including Blood, Nature Immunology, Seminars of Hematology and Leukemia. He has also authored multiple book chapters. Dr. Pinilla-Ibarz received both his MD and PhD from the University of Zaragoza, School of Medicine, Spain. He completed his residency in medicine and a fellowship in Hematology at La Paz University Hospital in Madrid, Spain; and after he moved to the US, he also completed a residency in Internal Medicine at Cornell Medical Center and a fellowship in Hematology/Oncology at the Memorial Sloan Kettering Cancer Center in New York City.

Kenneth H. Shain, MD, PhD

Assistant Member, Departments of Malignant Hematology & Tumor Biology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA

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Dr. Kenneth Shain is an Assistant Member at the H. Lee Moffitt Cancer Center and Research Institute (Moffitt), with a primary appointment in the Department of Malignant Hematology, and a secondary appointment in the Department of Tumor Biology. He also serves as the Scientific Director of the Moffitt Myeloma Working Group (MMWG) and as the Director of the ORIEN MM Disease Interest Group (DIG) at Moffitt. 

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As a clinician-scientist he investigates the pathobiology of multiple myeloma (MM) and mechanisms of therapy resistance, including intrinsic mechanisms of resistance and that mediated by bone marrow tumor microenvironment (TME), to identify novel targets and tools to improve the management of multiple myeloma (MM). On the clinical side he treats MM patients and directs MM clinical trials. Dr. Shain's research has three major focuses: (i) development and use of pharmacoproteomic tools to identify vulnerabilities of MM and to identify drivers of therapy resistance in the context of the TME; (ii) development and use of ex vivo tools informed by mathematical models for personalized management of MM; and (iii) development and use of tissue, molecular and clinical bio-repositories/databases centered around gene expression profiling, whole exome sequencing (WES) and RNA sequencing (RNAseq) of MM patient specimens, to identify predictive and prognostic molecular biomarkers. The ultimate objective of Dr. Shain's research program is to address the critical need to identify tractable vulnerabilities to inform the development of targeted therapeutics with biomarkers facilitating truly personalized management in MM.